Dipeptidyl Peptidase
DPP
Dipeptidyl Peptidases are widely distributed exopeptidases that possess central role in proteolysis. The dipeptidyl peptidase family, including DPP-IV DPP7, DPP8, DPP9, fibroblast activation protein and others, cleave the peptide bond after the penultimate proline residue and are drug target rich.
DPP-IV (DPP4 or CD26) is a serine protease detected on several immune cells and on epithelial cells of various organs. Besides the membrane-bound enzyme, a catalytically active soluble form is detected in several body fluids. Both variants cleave off dipeptides from the N-termini of various chemokines, neuropeptides, and hormones. DPP IV plays a key role in immune-regulation, inflammation, oxidative stress, cell adhesion, and apoptosis by targeting different substrates. DPP IV inhibitors are commonly used as hypoglycemic agents.
DPP8 and DPP9 show DPPIV-like activity and share a very high-sequence similarity to each other. DPP8 and DPP9 are intracellular N-terminal dipeptidyl peptidases (preferentially postproline) associated with pathophysiological roles in immune response and cancer biology.
Dipeptidyl Peptidase Isoform Specific Products
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Dipeptidyl Peptidase Inhibitors
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Dipeptidyl Peptidase Antagonist
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Dipeptidyl Peptidase Activator
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Dipeptidyl Peptidase Controls
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Dipeptidyl Peptidase Substrates
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DPP IV/CD26 Proteins
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Dipeptidyl Peptidase Related Products (239)
Related Products (239)
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Recombinant Proteins (9)
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Antibodies (1)
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Dipeptidyl Peptidase Isoform Comparison
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Fluostatin A sodium
0 ImagesCat. No.: HY-N14989ACAS No.: 209673-93-8Fluostatin A sodium is a dipeptidyl peptidaseIII inhibitor with an IC50 of 0.44 μg/mL. Fluostatin A can be extracted from Streptomyces sp. TA-3391.
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Fluostatin A
0 ImagesCat. No.: HY-N14989CAS No.: 160219-74-9Fluostatin A inhibits the ability of DPP-III, and with arginyl-arginine-2-naphthalene formamide as the substrate, the IC50 is 0.44 μg/mL.
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SGLT2-IN-6
0 ImagesCat. No.: HY-180528SGLT2-IN-6 (Compound 101) is an orally active SGLT2 inhibitor with IC₅₀ values for SGLT2, SGLT1, and DPP4 of 0.8, 6.7, and 72 nM respectively. SGLT2-IN-6 controls blood sugar levels in diabetic rat models and increases the levels of active GLP-1. SGLT2-IN-6 can be used for the study of type 2 diabetes.
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Teneligliptin-d5
0 ImagesCat. No.: HY-14806S2Synonyms: MP-513-d5Teneligliptin-d5 (MP-513-d5) is deuterium labeled Teneligliptin. Teneligliptin (MP-513) hydrobromide hydrate is an orally active and selective dipeptidyl peptidase 4 (DPP-4) inhibitor (IC50s: 0.37 and 0.29 nM for the human and rat DPP-4, respectively). Teneligliptin hydrobromide hydrate improves blood glucose levels and can be used in researches related to type 2 diabetes mellitus.
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AMG-222 tosylate
0 ImagesCat. No.: HY-19859CAS No.: 1163719-08-1AMG-222 (tosylate) is a DPP-IV inhibitor that can be used in the research of type II diabete.
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cis-ICeD-2
0 ImagesCat. No.: HY-151871Acis-ICeD-2 is the cis isomer of ICeD-2 (HY-151871). ICeD-2 is a cell death inducer that induces cell death in HIV-1-infected cells. ICeD-2-mediated killing of HIV-1-infected cells is dependent on HIV-1 protease activity. ICeD-2 effectively blocks the hydrolysis of Gly-Pro-AMC by the dipeptidyl peptidases DPP8 and DPP9. ICeD-2 demonstrates strong stability against DPP9 in PBMCs..
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(Rac)-Sitagliptin-d4-1 hydrochloride
0 ImagesCat. No.: HY-132489S1CAS No.: 2749855-96-5Synonyms: (Rac)-MK-0431-d4-1 hydrochloride(Rac)-Sitagliptin-d4-1 hydrochloride ((Rac)-MK-0431-d4-1 hydrochloride) is the deuterium labeled (Rac)-Sitagliptin-1 hydrochloride. (Rac)-Sitagliptin is an isoform of Sitagliptin (HY-13749), which is a potent and orally active inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts.
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Fluostatin B
0 ImagesCat. No.: HY-N15181CAS No.: 158906-40-2Fluostatin B is a dipeptidyl peptidase 3 (DPP-3) inhibitor with an IC50 value of 24 µg/mL. Fluostatin B is a fluorenone, which is found in Streptomyces.
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Acetyl-L-Ieucyl-L-argininal
0 ImagesCat. No.: HY-N15105CAS No.: 35039-75-9Acetyl-L-Ieucyl-L-argininal shows inhibition of peptidyl amin-peptidase III activity.
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Dioctatin A hydrochloride
0 ImagesCat. No.: HY-134666ADioctatin A hydrochloride is a metabolite of Streptomyces and an inhibitor of human dipeptidyl aminopeptidase II. Dioctatin A hydrochloride can inhibit aflatoxin production by Aspergillus parasiticus with an IC50 of 4.0 μM. Dioctatin A hydrochloride can reduce the mRNA levels of aflatoxin biosynthetic genes and the regulatory gene aflR, inhibit conidiation and decrease the mRNA level of the brlA gene, and also promote kojic acid production. In addition, Dioctatin A hydrochloride can inhibit sterigmatocystin production. Dioctatin A hydrochloride has pleiotropic regulatory effects on the production and differentiation of fungal secondary metabolites.
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Brensocatib (Standard)
0 ImagesCat. No.: HY-101056RCAS No.: 1802148-05-5Synonyms: AZD7986 (Standard); INS 1007 (Standard)Brensocatib (Standard) is the analytical standard of Brensocatib (HY-101056). This product is intended for research and analytical applications. Brensocatib (AZD7986) is an oral dipeptidyl peptidase 1 (DPP1) inhibitor with pIC50s of 6.85, 7.6, 7.7, 7.8, and 7.8 in human, mouse, rat, dog and rabbit, respectively.
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Anagliptin-d7
0 ImagesCat. No.: HY-14877S1Synonyms: SK-04037Anagliptin-d7 (SK-0403-d7) is deuterium labeled Anagliptin. Anagliptin (SK-0403) is a highly selective, potent, orally active inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC50 of 3.8 nM, and less selective at DPP-8 and DDP-9 with IC50s of 68 nM and 60 nM, respectively.
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Dutogliptin (Standard)
0 ImagesCat. No.: HY-10286RCAS No.: 852329-66-9Synonyms: PHX-1149 free base (Standard)Dutogliptin (Standard) is the analytical standard of Dutogliptin (HY-10286). This product is intended for research and analytical applications. Dutogliptin (PHX-1149 free base) is an orally available, potent, and selective dipeptidyl peptidase-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus.
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H-Gly-Pro-Hyp-OH acetate
0 ImagesCat. No.: HY-A0299ACAS No.: 103192-50-3H-Gly-Pro-Hyp-OH acetate is a dipeptidyl peptidase 4 (DPP-4) inhibitor with an IC50 value of 2.51 mM. H-Gly-Pro-Hyp-OH acetate is promising for research of diabetes.
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ASP4000 free base
0 ImagesCat. No.: HY-167075CAS No.: 851510-67-3ASP4000 free base is an orally effective dipeptidyl peptidase 4 (DPP4) inhibitor, with an IC50 value of 2.25 nM against human recombinant DPP4, and exhibits hypoglycemic activity. By inhibiting DPP4 activity, ASP4000 free base reduces the degradation of active glucagon-like peptide-1 (GLP-1), thereby persistently increasing postprandial active GLP-1 levels and improving glycemic control. ASP4000 free base can be used in studies related to type 2 diabetes.
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Saxagliptin-13C2
0 ImagesCat. No.: HY-10285S2Synonyms: BMS-477118-13C2Saxagliptin-13C2 (BMS-477118-13C2) is 13C labeled Saxagliptin. Saxagliptin (BMS-477118) is a potent, selective, reversible, competitive and orally active dipeptidyl peptidase-4 (DPP-4) (Ki = 0.6-1.3 nM) inhibitor. Saxagliptin has the peotential for type 2 diabetes mellitus research.
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(–)-Sitagliptin carbamoyl glucuronide
0 ImagesCat. No.: HY-Z3637CAS No.: 940002-59-5(–)-Sitagliptin carbamoyl glucuronide is a minor metabolite of the dipeptidyl peptidase 4 (DPP-4) inhibitor Sitagliptin (HY-13749).
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Alogliptin (Standard)
0 ImagesSynonyms: SYR-322 free base (Standard)Alogliptin (Standard) is the analytical standard of Alogliptin. This product is intended for research and analytical applications. Alogliptin (SYR-322 free base) is a potent, selective and orally active inhibitor of DPP-4 with an IC50 of <10 nM, and exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. Alogliptin can be used for the research of type 2 diabetes.
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Anagliptin (Standard)
0 ImagesCat. No.: HY-14877RCAS No.: 739366-20-2Synonyms: SK-0403 (Standard)Anagliptin (Standard) is the analytical standard of Anagliptin. This product is intended for research and analytical applications. Anagliptin (SK-0403) is a highly selective, potent, orally active inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC50 of 3.8 nM, and less selective at DPP-8 and DDP-9 with IC50s of 68 nM and 60 nM, respectively.
